Retinoyl β-Glucuronide: A Biologically Active Interesting Retinoid
نویسندگان
چکیده
منابع مشابه
Induction of differentiation of human promyelocytic leukemia cell line HL-60 by retinoyl glucuronide, a biologically active metabolite of vitamin A.
We examined the differentiation activity of retinoyl beta-D-glucuronide, a biologically active physiological metabolite of vitamin A, using the human promyelocytic leukemic cell line HL-60, which can be induced to differentiate with retinoic acid. Retinoyl beta-D-glucuronide (1 microM) inhibited HL-60 cell proliferation by 55-75%, inhibited tritiated thymidine incorporation into DNA by 63-80%, ...
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Soon after [1 1-3H]retinoic acid (RA) (1.1 x 108 d.p.m.) was administered orally to rats either as a large dose (115 ,ug = 0.38 /tmol/rat) or mixed with unlabelled RA as a huge dose (22 mg = 73.33 ,umol/rat), retinoyl ,-glucuronide (RAG) was identified and characterized as a significant metabolite in the serum and small intestine. Of the administered dose, 70 % remained unchanged as retinoic ac...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2004
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/134.1.286s